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- • Responses are more frequent as larger doses are given, but higher doses cause unacceptable side effects much
- more often. Some physicians start their patients at a low dosage of interferon and gradually increase it. This
- appears to result in fewer side effects when the higher dosage is eventually reached, but obviously the KS
- takes longer to respond.
- • Studies of interferon plus chemotherapy have failed to produce any consistent improvement over either agent
- used by itself.
- • AZT has been added to interferon with some suggestion of increased effect.
- • Because one of the most worrisome side effects of chemotherapy is the depression of white blood cell counts,
- with the risk of subsequent infections, G-CSF or GM-CSF may help to maintain the blood counts so that
- adequate treatment may be given.